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PROCESS: Evaluating how the PRIME intervention worked in practice

Start date: 1 Apr 2011

[Project summary in Français / Português]

Scientific title: What is the process, context and impact of the PRIME health facility intervention and how can this explain the findings of the trial’s endpoints?  

Latest on this research

[Français / Português]

Scroll down to find the publications on the results of this study.

Learn more about PRIME, the study from which PROCESS developed from.

Download the PRIME & PROCESS policy brief and the PRIME training manuals.

What did we know before this research?

The PRIME intervention was designed by an ACT Consortium research study to improve health centre management, fever case management and patient centred services at Ugandan health centres.

A cluster randomised trial is evaluating the impact of the PRIME intervention on the health outcomes of community children and the appropriateness of antimalarial treatment they receive. The PROCESS project is a complementary evaluation study that runs alongside this trial.

This PROCESS study is evaluating the implementation, mechanisms of change, context and consequences of the PRIME intervention. Comprehensive process evaluations are often recommended, but less commonly undertaken. This research sets up a protocol which provides an example of an empirical study that puts this recommendation into practice.

What does this study add?

This study uses a theory-driven approach, aiming to articulate and evaluate the intended implementation of the PRIME intervention and its intended pathway of change.

The study uses a logic model to set out and test intended mechanisms and conditions for enabling or preventing change. The study also aims to interpret the impact of the intervention in the context of the daily lives of health workers and patients.

The study uses mixed methods, including in-depth interviews, questionnaires and focus group discussions to elicit the perspectives and experiences of different people who were part of or close to the intervention.

Our informants include health care workers, patients, community members, community stakeholders, district officials and implementers of the intervention.

The evaluation is being conducted over two years from the start of the intervention. This will allow us to interpret how the intervention is incorporated, adjusted or discarded over time. This will inform future programmes on how interventions can stimulate behavior change in health services.

The research team

Principal Investigator

  • Dr. Sarah Staedke, London School of Hygiene & Tropical Medicine 


  • Prof Moses Kamya, Professor, Makerere University, Uganda

Other Investigators:

  • Dr Grant Dorsey, Associate Professor, University of California, San Francisco
  • Dr Clare Chandler, Lecturer, London School of Hygiene & Tropical Medicine

Research Themes

Related Publications

The PROCESS study: a protocol to evaluate the implementation, mechanisms of effect and context of an intervention to enhance public health centres in Tororo, Uganda

Clare IR Chandler, Deborah DiLiberto, Susan Nayiga, Lilian Taaka, Christine Nabirye, Miriam Kayendeke, Eleanor Hutchinson, James Kizito, Catherine Maiteki-Sebuguzi, Moses R Kamya and Sarah G Staedke  |  Published
Implementation Science

Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic Falciparum Malaria infections in Uganda

Stephen Tukwasibwe, Levi Mugenyi, George W. Mbogo, Sheila Nankoberanyi, Catherine Maiteki-Sebuguzi, Moses L. Joloba, Samuel L. Nsobya, Sarah G. Staedke and Philip J. Rosenthal  |  Published
Journal of Infectious Diseases

The practice of 'doing' evaluation: lessons learned from nine complex intervention trials in action

Joanna R, Deborah D, Lindsay M, Evelyn A, Sham L, Hilda M, Katia B, Jayne W, Lasse V, Shunmay Y, Toby L, Eleanor H, Hugh R, David L, David S, Bonnie C, Sarah S, Virginia W, Catherine G, Clare C  |  Published
Implementation Science

Strengthening patient-centred communication in rural Ugandan health centres: A theory-driven evaluation within a cluster randomized trial

Susan Nayiga, Deborah DiLiberto, Lilian Taaka, Christine Nabirye, Ane Haaland, Sarah G. Staedke, Clare I. R. Chandler  |  Published

Challenging logics of complex intervention trials: Community perspectives of a health care improvement intervention in rural Uganda

Ferdinand M. Okwaroa, Clare I.R. Chandler, Eleanor Hutchinson, Christine Nabirye, Lilian Taaka, Miriam Kayendeke, Susan Nayiga, Sarah G. Staedke  |  Published
Social Science & Medicine

Behind the scenes of the PRIME intervention: designing a complex intervention to improve malaria care at public health centres in Uganda

Deborah D. DiLiberto, Sarah G. Staedke, Florence Nankya, Catherine Maiteki-Sebuguzi, Lilian Taaka, Susan Nayiga, Moses R. Kamya, Ane Haaland and Clare I. R. Chandler  |  Published
Global Health Action

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